A new study shows that defects in SECIS-binding protein 2 (SBP2), a factor required for incorporation of selenium into proteins, produce alterations in thyroid hormone metabolism in humans but none of the other effects attributed to selenium deficiency or loss of selenoproteins. This finding suggests that SBP2 has a role in distinguishing between selenoproteins whose functions are essential and those with supporting roles in life and health.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Biogenic selenium and its hepatoprotective activity
Scientific Reports Open Access 15 November 2017
-
Selenoprotein N is dynamically expressed during mouse development and detected early in muscle precursors
BMC Developmental Biology Open Access 22 August 2009
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hatfield, D.L. & Gladyshev, V.N. Mol. Cell. Biol. 22, 3565–3576 (2002).
Beck, M.A. Handy, J. & Levander, O.A. Trends Microbiol. 12, 417–423 (2004).
Bosl M.R., Takaku K., Oshima M., Nishimura S. & Taketo M.M. Proc. Natl. Acad. Sci. USA 94, 5531–5534 (1997).
Carlson, B.A. et al. J. Biol. Chem. 279, 8011–8017 (2004).
Dumitrescu, A. et al. Nat Genet. 37, 1247–1252 (2005).
Driscoll, D.M. & Copeland, P.R. Annu. Rev. Nutr. 23, 17–40 (2003).
Behne, D., Hilmert, H., Scheid, S., Gessner, H. & Elger, W. Biochim. Biophys. Acta. 966, 12–21 (1988).
Low, S.C., Grundner-Culemann, E., Harney, J.W. & Berry, M.J. EMBO J. 19, 6882–6890 (2000).
Copeland, P.R., Fletcher, J.E., Carlson, B.A., Hatfield, D.L. & Driscoll, D.M. EMBO J. 19, 306–314 (2000).
Chavatte, L., Brown, B.A. & Driscoll, D.M. Nat. Struct. Mol. Biol. 12, 408–416 (2005)
Yant, L.J. et al. Free Radic. Biol. Med. 34, 496–502 (2003).
Jakupoglu, C. et al. Mol. Cell. Biol. 25, 1980–1988 (2005).
Conrad, M. et al. Mol. Cell. Biol. 24, 9414–9423 (2004).
Freedman, J.E. et al. J. Clin. Invest. 97, 979–987 (1996).
Kenet, G. et al. Arterioscler. Thromb. Vasc. Biol. 19, 2017–2023 (1999).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Berry, M. Insights into the hierarchy of selenium incorporation. Nat Genet 37, 1162–1163 (2005). https://doi.org/10.1038/ng1105-1162
Issue Date:
DOI: https://doi.org/10.1038/ng1105-1162
This article is cited by
-
From Selenium Absorption to Selenoprotein Degradation
Biological Trace Element Research (2019)
-
The unique tRNASec and its role in selenocysteine biosynthesis
Amino Acids (2018)
-
Biogenic selenium and its hepatoprotective activity
Scientific Reports (2017)
-
The C718T polymorphism in the 3′-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension
Hypertension Research (2012)
-
Molecular cloning, characterization and mRNA expression analysis of a novel selenoprotein: avian selenoprotein W from chicken
Molecular Biology Reports (2011)