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Letter

Nature Genetics 37, 1113–1118 (1 October 2005) | doi:10.1038/ng1646

A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

David Reich , Nick Patterson , Philip L De Jager , Gavin J McDonald , Alicja Waliszewska , Arti Tandon , Robin R Lincoln , Cari DeLoa , Scott A Fruhan , Philippe Cabre , Odile Bera , Gilbert Semana , M Ann Kelly , David A Francis , Kristin Ardlie , Omar Khan , Bruce A C Cree , Stephen L Hauser , Jorge R Oksenberg & David A Hafler

Multiple sclerosis is a common disease with proven heritability, but, despite large-scale attempts, no underlying risk genes have been identified. Traditional linkage scans have so far identified only one risk haplotype for multiple sclerosis (at HLA on chromosome 6), which explains only a fraction of the increased risk to siblings.