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Volume 36 Issue 2, February 2004

Cover art: Family Tree (Indonesia 1997, batik artist unknown)

Editorial

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Book Review

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News & Views

  • Recent work shows that one pathway to flowering involves a complex that modulates the chromatin structure of the flowering repressor FLOWERING LOCUS C and that a component of this flowering complex is also involved in regulation of a cold-response gene.

    • Richard Amasino
    News & Views
  • The tumor-suppressor protein p53 mediates the response of mammalian cells to DNA damage. Studies now show that DNA damage elicits quantal pulses of p53, with greater damage eliciting more pulses.

    • John J Tyson
    News & Views
  • New work has directly estimated male gene conversion rates in three regions of the human genome and identified gene conversion hot spots in the same locations as previously identified crossover hot spots. This work elucidates the fine-scale structure of linkage disequilibrium (LD) in the human genome and will be useful in association studies and other LD-based applications in population and human genetics.

    • Jeffrey D Wall
    News & Views
  • AKT1 is a protein kinase that functions as a central element in many pathways involved in the control of cell growth and apoptosis. Genetic and biochemical data now provide evidence that AKT1 may be a susceptibility gene for schizophrenia.

    • Joachim Hallmayer
    News & Views
  • The tumor suppressor gene RASSF1 contributes to the spatiotemporal regulation of mitosis through a new mechanism. By interacting with Cdc20, its protein product RASSF1A inhibits the anaphase-promoting complex and prevents degradation of cyclin A and cyclin B until the spindle checkpoint becomes fully operational.

    • Endre Máthé
    News & Views
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Article

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Letter

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Technical Report

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