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Brief Communication
Nature Genetics 36, 1056–1058 (1 October 2004) | doi:10.1038/ng1432
Metabolic gene|[ndash]|deletion strains of Escherichia coli evolve to computationally predicted growth phenotypes
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Abstract
Genome-scale metabolic models have a promising ability to describe cellular phenotypes accurately. Here we show that strains of Escherichia coli carrying a deletion of a single metabolic gene increase their growth rates (by 87% on average) during adaptive evolution and that the endpoint growth rates can be predicted computationally in 39 of 50 (78%) strains tested.
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