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Letter

Nature Genetics 34, 337–343 (1 July 2003) | doi:10.1038/ng1183

OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer

Grant C Sellar , Karen P Watt , Genevieve J Rabiasz , Euan A Stronach , Li Li , Eric P Miller , Charles E Massie , Jayne Miller , Bruno Contreras-Moreira , Diane Scott , Iain Brown , Alastair R Williams , Paul A Bates , John F Smyth & Hani Gabra

Epithelial ovarian cancer (EOC), the leading cause of death from gynecological malignancy, is a poorly understood disease. The typically advanced presentation of EOC with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases are hallmarks of the disease.