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Letter
Nature Genetics 34, 326–329 (1 July 2003) | doi:10.1038/ng1172
Cadmium is a mutagen that acts by inhibiting mismatch repair
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Abstract
Most errors that arise during DNA replication can be corrected by DNA polymerase proofreading or by post-replication mismatch repair (MMR). Inactivation of both mutation-avoidance systems results in extremely high mutability that can lead to error catastrophe.
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