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Brief Communication

Nature Genetics 29, 139–140 (1 October 2001) | doi:10.1038/ng1001-139

Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males

Hiroki Kurahashi & Beverly S. Emanuel

Junction fragments from the constitutional t(11;22)(q23;q11) translocation have previously been cloned and sequenced. Here we report a high incidence of translocation-specific PCR products in sperm DNA from normal individuals.