Access

Letter

Nature Genetics 25, 91–95 (1 May 2000) | doi:10.1038/75664

Mutations in KERA, encoding keratocan, cause cornea plana

Natalia S. Pellegata , Jose L. Dieguez-Lucena , Tarja Joensuu , Stephanie Lau , Kate T. Montgomery , Ralf Krahe , Tero Kivel|[auml]| , Raju Kucherlapati , Henrik Forsius & Albert de la Chapelle

Specialized collagens and small leucine-rich proteoglycans (SLRPs) interact to produce the transparent corneal structure. In cornea plana, the forward convex curvature is flattened, leading to a decrease in refraction.