Nature Genetics
21, 5 - 9 (1999)
doi:10.1038/4429
Molecular interactions on microarraysEdwin Southern, Kalim Mir
& Mikhail Shchepinov
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
ems@bioch.ox.ac.uk
The structural features of nucleic acid probes tethered to a solid support
and the molecular basis of their interaction with targets in solution have
direct implications for the hybridization process. We discuss how arrays of
oligonucleotides provide powerful tools to study the molecular basis of these
interactions on a scale which is impossible using conventional analysis.
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