Liver spatiotemporal transcriptomics
Two studies characterize spatiotemporal transcriptional dynamics during liver homeostasis, cholestatic injury and regeneration in mice.
Two studies characterize spatiotemporal transcriptional dynamics during liver homeostasis, cholestatic injury and regeneration in mice.
We used high-throughput transposon screens to examine the responses of generalist and host-adapted Salmonella enterica serovars to 25 stress conditions that recapitulate key stages of human infection. We identified and characterized numerous typhoid-specific gene networks, revealing a role for specific pseudogenes in shaping bacterial fitness outcomes.