Nature Genetics - CURRENT ISSUE : July 2008 - Vol 40 No 7
- De novo copy number variation in schizophrenia
- NQO1 genotype predicts breast cancer outcomes
- Pigmentation and melanoma susceptibility
LATEST HIGHLIGHTS
Advance Online Publication
Leif Andersson and colleagues report that a 4.6-kb duplication in intron 6 of the gene encoding syntaxin 17, which promotes overexpression of both STX17 and the neighboring gene NR4A3, is responsible for the loss of hair pigmentation in Gray horses.
Advance Online Publication
Gregory Barsh and colleagues show that two loci for dark skin in mice result from mutations in the genes encoding ribosomal proteins S19 and S20. They further show that the pleiotropic effects of these mutations are mediated through stabilization of p53.
Advance Online Publication
Shiro Ikegawa and colleagues identify variation in a previously unknown gene, DVWA, that is associated with susceptibility to knee osteoarthritis. DVWA is expressed in cartilage and binds to β-tubulin, which has been reported to have chondrogenic properties.
Advance Online Publication
Mitinori Saitou and colleagues report that Prdm14, which encodes a transcription factor expressed exclusively in the germ cell lineage, is essential for re-acquisition of pluripotency and epigenetic reprogramming of primordial germ cells.
CONFERENCE
The Genomics of Common Diseases 2008
ConferenceNature Genetics in association with The Wellcome Trust is pleased to announce the second Genomics of Common Diseases meeting, to be held September 6–9, 2008 at The Broad Institute of MIT and Harvard in Cambridge, MA, USA. The meeting will feature emerging insights into the genetic architecture of complex disorders, and explore the shift toward understanding disease mechanisms and potential applications.
FOCUS
Focus on rat genetics
FocusIn this, the 'Year of the Rat', Nature Genetics is proud to present a special focus on rat genetics. The focus features two comprehensive overviews of the state of the field and the online resources available to investigators, as well as a series of primary research papers presenting the latest discoveries of genes influencing complex traits.
