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Published online 8 November 2009 |
Nature
| doi:10.1038/news.2009.1070
Corrected online: 10 November 2009
News
Faster route to stem-like cells
All adult cells can be reprogrammed, researchers claim.
Given the right conditions, any adult cell can be coaxed into becoming stem-cell like, according to a team of researchers based in the United States. The team, led by Rudolf Jaenisch of the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, were also able to speed up the process, cutting the time required for cells to become stem-cell like by around half.
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The CORRECTION is very interesting. It changed a clear description of positive correlation between accelerated generation of iPS cells and increased expression of cancer-related genes (as indicated by the research paper) to an ambiguous relationship of a change (what change?) in the expression of cancer-related genes with the accelerated iPS cell generation. Why?
I need some help from a mathematician! If one get a primary iPS reprogramming (starting from non-iPS cells and using inducing factors of course) efficiency of 0.01% and then get a >92% “reprogramming†(without using any “iPSizing†factor) efficiency for “new†iPS cells from secondary iPS cells (derived from the primary iPS cells). What would be the overall iPS reprogramming efficiency?
By the way, I submitted a Communications Arising on this to Nature which is entitled "Outright misrepresentation should be an easy target amenable to invalidation".