Next-generation sequencing provides the most accurate estimate to date.
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References
Xue, Y. et al. Curr. Biol. (2009) doi:10.1016/j.cub.2009.07.032.
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Dolgin, E. Human mutation rate revealed. Nature (2009). https://doi.org/10.1038/news.2009.864
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DOI: https://doi.org/10.1038/news.2009.864