Proteins with 'zinc fingers' designed to bind almost any DNA sequence will soon be available to any lab that wants them — from two very different sources. Helen Pearson reports on a revolution in designer biology.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
ZFNGenome: A comprehensive resource for locating zinc finger nuclease target sites in model organisms
BMC Genomics Open Access 28 January 2011
-
Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences
BMC Bioinformatics Open Access 02 November 2010
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Doyon, Y. et al. Nature Biotechnol. 26, 702–708 (2008).
Meng, X., Noyes, M. B., Zhu, L. J., Lawson, N. D. & Wolfe, S. A. Nature Biotechnol. 26, 695–701 (2008).
Woods, I. G. & Schier, A. F. Nature Biotechnol. 26, 650–651 (2008).
Perez, E. E. et al. Nature Biotechnol. 26, 808–816 (2008).
Maeder, M. L. et al. Mol. Cell 31, 294–301 (2008).
Miller, J., McLachlan, A. D. & Klug, A. EMBO J. 4, 1609–1614 (1985).
Pavletich, N .P. & Pabo, C. O. Science 252, 809–817 (1991).
Isalan, M., Klug, A. & Choo, Y. Nature Biotechnol. 19, 656–660 (2001).
Joung, J. K., Ramm, E. I. & Pabo, C. O. Proc. Natl Acad. Sci. USA 97, 7382–7387 (2000).
Kim, Y. G., Cha, J. & Chandrasegaran, S. Proc. Natl Acad. Sci. USA 93, 1156–1160 (1996).
Urnov, F. D. et al. Nature 435, 646–651 (2005).
Additional information
There is a Correction associated with this article: the name of Matthew Porteus of the University of Texas was mispelled. This has now been corrected online.
Related links
Related links
Related links in Nature Research
Related external links
Rights and permissions
About this article
Cite this article
Pearson, H. Protein engineering: The fate of fingers. Nature 455, 160–164 (2008). https://doi.org/10.1038/455160a
Published:
Issue Date:
DOI: https://doi.org/10.1038/455160a
This article is cited by
-
ZFNGenome: A comprehensive resource for locating zinc finger nuclease target sites in model organisms
BMC Genomics (2011)
-
Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)
Nature Methods (2011)
-
Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences
BMC Bioinformatics (2010)