Botilinum can travel along nerves and degrade proteins in the brain stem.
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References
Antonucci, F., Rossi, C., Gianfranceschi, L., Rossetto, O. & Caleo, M. J. Neurosci. 28, 3689-3696 (2008).
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Smith, K. Botox toxin gets into rat brains. Nature (2008). https://doi.org/10.1038/news.2008.719
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DOI: https://doi.org/10.1038/news.2008.719