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How does the binding of agonist lead to a change in ion channel gating? Kohda and colleagues take advantage of the lurcher mutation to provide new insights into how binding of glutamate affects channel gating for AMPA, kainate and NMDA receptors.
A study of ocular dominance plasticity in mice lacking a synthetic enzyme for GABA suggests that increased cortical inhibition initiates the critical period for plasticity in primary visual cortex.
Jagota and colleagues show that sectioning the suprachiasmatic nucleus in a different orientation than usual reveals two peaks of circadian activity, consistent with behavioral rhythms in vivo.
A simple model suggests that activity in primary motor cortex may encode the activity of individual muscles and not higher-order features as previously suspected.
