Volume 25 Issue 12, December 2022

The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases.

Martinez et al. identified the protein interactome of the tau seed responsible for propagation. The authors found how the presynaptic protein Bassoon interacts with the tau seed enhancing its stability and subsequently tau toxicity and spreading.

Zambusi, Novoselc et al. show that granulin-mediated clearance of cytoplasmic TDP-43⁺ condensates and lipid droplets in injury-activated microglia is required for their return to the homeostatic state and successful brain regeneration.

Karpf et al. showed that distinct layers of the adult human and mouse DG are populated by astrocytes, which exhibit a subtype-specific molecular profile and morphology, leading to subtype-specific physiological characteristics.

This study shows that burst-firing-induced astrocyte signaling potentiates glutamatergic transmission onto dopamine neurons in mouse VTA.

Yu et al. show that at least two distinct serotonergic DRN-to-BA pathways are involved in different aspects of anxiety-related behaviors via different molecular mechanisms.

Using chronic neural recordings, the authors show that long-term stability in both skilled and natural behaviors is associated with stable single neuron activity patterns in relevant motor circuits.

Liu and colleagues show that REM sleep in mice can be divided into two distinct substages and that the RSC dictates global cortical dynamics during sleep and plays a role in regulating transitions between REM sleep substages.

Motor planning can improve performance but can also lead to premature actions. The authors show that the anterior lateral motor cortex plays an important role in impulsive behavior by encoding and influencing premature motor output.

Model-based analysis of learning and neural activity in mice trained to find reward in both a spatial, navigational context and a relational, non-navigational context revealed dissociable contributions of hippocampus depending upon spatial context.

Using dual-color mesoscopic imaging in the neocortex of awake mice, the authors show that cholinergic release and neuronal activity exhibit distinct spatiotemporal patterns that are differentially linked to spontaneous fluctuations in behavioral state.

Chiou et al. provide a multiregion bulk (N = 527 samples) and single-nucleus (N = 24 samples) brain transcriptional dataset encompassing 15 brain regions and both sexes in a unique population of free-ranging, behaviorally phenotyped rhesus macaques.

Zhu et al. develop a deep learning method to precisely infer single-trial neural dynamics from calcium imaging with subframe temporal resolution, which shows improvement over the state-of-the-art methods in capturing high-frequency dynamics and predicting behavior.