Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
This commentary provides a nuanced discussion on the conceptual framework to study epigenetic mechanisms that regulate brain function and plasticity. By drawing from examples in genomic imprinting, the authors highlight the challenges facing epigenetics research in the context of neuroscience.