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Brief Communication
Nature Neuroscience - 9, 1096 - 1098 (2006)
Published online: 20 August 2006; | doi:10.1038/nn1755

Representation of interaural time delay in the human auditory midbrain

Sarah K Thompson1, 4, Katharina von Kriegstein2, 3, 4, Adenike Deane-Pratt1, Torsten Marquardt1, Ralf Deichmann2, Timothy D Griffiths2, 3 & David McAlpine1

1  Department of Physiology and UCL Ear Institute, University College London, 332 Gray's Inn Road, London WC1X 8EE, UK.

2  Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK.

3  Auditory Group, Medical School, 1 Framlington Place, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne NE2 4HH, UK.

4  These two authors contributed equally to this work.

Correspondence should be addressed to David McAlpine d.mcalpine@ucl.ac.uk

Interaural time difference (ITD) is a critical cue to sound-source localization. Traditional models assume that sounds leading at one ear, and perceived on that side, are processed in the opposite midbrain. Using functional magnetic resonance imaging we demonstrate that as the ITDs of sounds increase, midbrain activity can switch sides, even though perceived location remains on the same side. The data require a new model for human ITD processing.


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Nature Neuroscience
ISSN: 1097-6256
EISSN: 1546-1726
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