Nature Neuroscience 9, 1001 - 1003 (2006)
Published online: 2 July 2006; | doi:10.1038/nn1725
Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experienceAnubhuthi Goel1, 2, 5, Bin Jiang3, 4, 5, Linda W Xu1, Lihua Song1, Alfredo Kirkwood3 &
Hey-Kyoung Lee1, 21
Department of Biology, University of Maryland, College Park, Maryland 20742, USA. 2
Neuroscience and Cognitive Science (NACS) Program, University of Maryland, College Park, Maryland 20742, USA. 3
Department of Neuroscience, The Mind/Brain Institute, Johns Hopkins University, Baltimore, Maryland 21218, USA. 4
Current address: Brain Science Institute, Riken, Wako City, Saitama, Japan. 5
These authors contributed equally to this work.
Correspondence should be addressed to Hey-Kyoung Lee hlee21@umd.edu Lack of a sensory input not only alters the cortical circuitry subserving the deprived sense, but also produces compensatory changes in the functionality of other sensory modalities. Here we report that visual deprivation produces opposite changes in synaptic function in primary visual and somatosensory cortices in rats, which are rapidly reversed by visual experience. This type of bidirectional cross-modal plasticity is associated with changes in synaptic AMPA receptor subunit composition.
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