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Chalk one up for 'nature' during neocortical neurogenesis

Nature Neuroscience volume 9, pages 717–718 (2006)Cite this article

During development, neurons destined for different neocortical layers are sequentially generated. Shen et al. report that this timing is programmed within individual progenitor cells and depends mainly on cell-intrinsic mechanisms.

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Figure 1: As early as E10.5, neocortical progenitors contain an intrinsic program that specifies the order in which different neuronal and glial cell types will be generated.

Ann Thomson

References

  1. Shen, Q. et al. Nat. Neurosci. 9, 743–751 (2006).

    Article  CAS  PubMed  Google Scholar 

  2. Temple, S. Nature 414, 112–117 (2001).

    Article  CAS  PubMed  Google Scholar 

  3. McConnell, S.K. J. Neurosci. 8, 945–974 (1988).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Frantz, G.D. & McConnell, S.K. Neuron 17, 55–61 (1996).

    Article  CAS  PubMed  Google Scholar 

  5. McConnell, S.K. & Kaznowski, C.E. Science 254, 282–285 (1991).

    Article  CAS  PubMed  Google Scholar 

  6. Fishell, G. Development 121, 803–812 (1995).

    CAS  PubMed  Google Scholar 

  7. Qian, X., Davis, A.A., Goderie, S.K. & Temple, S. Neuron 18, 81–93 (1997).

    Article  CAS  PubMed  Google Scholar 

  8. Qian, X. et al. Neuron 28, 69–80 (2000).

    Article  CAS  PubMed  Google Scholar 

  9. Davis, A.A. & Temple, S. Nature 372, 263–266 (1994).

    Article  CAS  PubMed  Google Scholar 

  10. Qian, X., Goderie, S.K., Shen, Q., Stern, J.H. & Temple, S. Development 125, 3143–3152 (1998).

    CAS  PubMed  Google Scholar 

  11. Shen, Q., Zhong, W., Jan, Y.N. & Temple, S. Development 129, 4843–4853 (2002).

    CAS  PubMed  Google Scholar 

  12. Bielle, F. et al. Nat. Neurosci. 8, 1002–1012 (2005).

    Article  CAS  PubMed  Google Scholar 

  13. Takiguchi-Hayashi, K. et al. J. Neurosci. 24, 2286–2295 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Grosskortenhaus, R., Pearson, B.J., Marusich, A. & Doe, C.Q. Dev. Cell 8, 193–202 (2005).

    Article  CAS  PubMed  Google Scholar 

  15. Hanashima, C., Li, S.C., Shen, L., Lai, E. & Fishell, G. Science 303, 56–59 (2004).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute for Cell Engineering and in the Department of Neurology, Johns Hopkins University, School of Medicine, 733 N. Broadway, BRB 715, Baltimore, 21205, Maryland, USA

    Ken-ichi Mizutani & Nicholas Gaiano

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  1. Ken-ichi Mizutani
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  2. Nicholas Gaiano
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Mizutani, Ki., Gaiano, N. Chalk one up for 'nature' during neocortical neurogenesis. Nat Neurosci 9, 717–718 (2006). https://doi.org/10.1038/nn0606-717

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