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Subcellular organization of GABAergic synapses: role of ankyrins and L1 cell adhesion molecules

Nature Neuroscience volume 9, pages 163–166 (2006)Cite this article

Abstract

In vertebrate nervous systems, different classes of synaptic inputs are often segregated into restricted compartments of target neurons. For example, distinct types of GABAergic interneurons preferentially innervate subcellular domains and have been implicated in the precise temporal regulation of integration within neurons and activity within networks. Recent studies suggest that the subcellular segregation of different classes of GABAergic synapses is largely genetically determined. The localization and signaling of L1 family immunoglobulin proteins recruited by ankyrin-based membrane adaptors might serve as compartmental labels, which contribute to subcellular synapse organization in cerebellar Purkinje neurons.

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Figure 1: Subcellular organization of GABAergic inputs.
Figure 2: Possible mechanisms directing GABAergic innervation at the AIS of cerebellar Purkinje neurons.

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Acknowledgements

I thank M. Hausser for comments on the manuscript. This work is supported by the US National Institutes of Health and the March of Dimes Birth Defects Foundation. The author is a Pew, EJLB and McKnight Scholar.

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  1. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724, USA

    Z Josh Huang

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Huang, Z. Subcellular organization of GABAergic synapses: role of ankyrins and L1 cell adhesion molecules. Nat Neurosci 9, 163–166 (2006). https://doi.org/10.1038/nn1638

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