Nature Neuroscience 9, 170 - 172 (2006)
Published online: 22 January 2006; | doi:10.1038/nn1637
Experience-dependent modification of mechanisms of long-term depressionJihoon Jo1, Simon M Ball2, Heon Seok1, Seog Bae Oh3, Peter V Massey2, Elek Molnar2, Zafar I Bashir2, 4
& Kwangwook Cho1, 41
Biomedical Science, School of Medicine and Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK. 2
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK. 3
Molecular and Cellular Neuroscience Program, Department of Physiology, College of Dentistry, Seoul National University, Yeongeon-Dong Chongno-Ku, Seoul 110-749, South Korea. 4
These authors contributed equally to this work.
Correspondence should be addressed to Kwangwook Cho K.Cho@sheffield.ac.uk Mechanisms of long-term potentiation and depression (LTP and LTD) change considerably during development, but the importance of these changes and the factors that control them is not clear. We found that visual experience triggered a switch in mechanisms of LTD in rat perirhinal cortex, an area critical for visual recognition memory. Thus, changes in synaptic plasticity mechanisms were correlated with the changing physiological demands on the CNS.
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