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Triggering the brain's pathology sensor

Nature Neuroscience volume 9, pages 1463–1464 (2006)Cite this article

Microglia, the brain's intrinsic immune cells, rapidly sense brain injury and help clear cellular debris. Haynes et al. now show that P2Y12 receptors are critical for activating microglia and directing them to the site of injury.

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Figure 1: P2Y12 receptor expression shows an inverse correlation with microglial activation.

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  1. Max Delbrück Center for Molecular Medicine, Robert-Rössle-Strasse 10, Berlin, 13082, Germany

    Helmut Kettenmann

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  1. Helmut Kettenmann
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Kettenmann, H. Triggering the brain's pathology sensor. Nat Neurosci 9, 1463–1464 (2006). https://doi.org/10.1038/nn1206-1463

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