Opioids are commonly thought of as compounds that alleviate pain. A new study finds that elevated levels of the opioid dynorphin can unexpectedly activate bradykinin receptors, contributing to the maintenance of neuropathic pain.
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Altier, C., Zamponi, G. Opioid, cheating on its receptors, exacerbates pain. Nat Neurosci 9, 1465–1467 (2006). https://doi.org/10.1038/nn1206-1465b
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DOI: https://doi.org/10.1038/nn1206-1465b