Nature Neuroscience
- 9, 1465 - 1467 (2006)
doi:10.1038/nn1206-1465b
Opioid, cheating on its receptors, exacerbates painChristophe Altier & Gerald W Zamponi
The authors are at the Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada. zamponi@ucalgary.ca
Opioids are commonly thought of as compounds that alleviate pain. A new study finds that elevated levels of the opioid dynorphin can unexpectedly activate bradykinin receptors, contributing to the maintenance of neuropathic pain.
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