Nature Neuroscience
8, 1002 - 1012 (2005)
Published online: 24 July 2005; | doi:10.1038/nn1511
Multiple origins of Cajal-Retzius cells at the borders of the developing palliumFranck Bielle1, Amélie Griveau1, 5, Nicolas Narboux-Nême1, 5, Sébastien Vigneau1, 4, Markus Sigrist2, Silvia Arber2, Marion Wassef1
& Alessandra Pierani1, 31
Centre National de la Recherche Scientifique-Unité Mixte de Recherche 8542, Ecole Normale Supérieure, 46 rue d'Ulm, 75005 Paris, France. 2
Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland, and Friedrich Miescher Institute, Maulbeerstrasse 66, 4058 Basel, Switzerland. 3
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA. 4
Current address: Unité Génétique Moléculaire Murine, Institut Pasteur, 28 rue du docteur Roux, 75724 Paris, France. 5
These authors contributed equally to this work.
Correspondence should be addressed to Alessandra Pierani pierani@biologie.ens.fr Cajal-Retzius cells are critical in cortical lamination, but very little is known about their origin and development. The homeodomain transcription factor Dbx1 is expressed in restricted progenitor domains of the developing pallium: the ventral pallium (VP) and the septum. Using genetic tracing and ablation experiments in mice, we show that two subpopulations of Reelin+ Cajal-Retzius cells are generated from Dbx1-expressing progenitors. VP- and septum-derived Reelin+ neurons differ in their onset of appearance, migration routes, destination and expression of molecular markers. Together with reported data supporting the generation of Reelin+ cells in the cortical hem, our results show that Cajal-Retzius cells are generated at least at three focal sites at the borders of the developing pallium and are redistributed by tangential migration. Our data also strongly suggest that distinct Cajal-Retzius subtypes exist and that their presence in different territories of the developing cortex might contribute to region-specific properties.
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