Nature Neuroscience
8, 988 - 990 (2005)
Published online: 10 July 2005; | doi:10.1038/nn1502
Cortical calcium waves in resting newborn miceHelmuth Adelsberger1, 2, Olga Garaschuk1, 2
& Arthur Konnerth11
Physiologisches Institut, Ludwig-Maximilians Universität München, Pettenkoferstr. 12, 80336
München, Germany. 2
These authors contributed equally to this work.
Correspondence should be addressed to Arthur Konnerth konnerth@lrz.uni-muenchen.de Using a new optical fiber−based approach, we demonstrate the presence of recurrent Ca2+ transients in cortical neurons of non-anesthetized newborn mice in vivo. These Ca2+ waves reflect the correlated activity of thousands of cells and were detected only in resting, but not in moving pups. Our results suggest that Ca2+-dependent cortical maturation occurs predominantly during the intermittent sleep-like resting periods that are characteristic for the first days of postnatal life.
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