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EphB2 gets a GRIP on the dendritic arbor

The postsynaptic protein GRIP1 is now shown to work with the receptor tyrosine kinase EphB2 to bind a kinesin microtubule motor protein. This causes dendritic transport of EphB2, triggering a pathway critical for establishment and maintenance of dendritic arbors.

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Figure 1: GRIP1 is crucial in the transport of EphB2 and in the formation of the dendritic arbor in hippocampal neurons.

Ann Thomson

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Misra, C., Ziff, E. EphB2 gets a GRIP on the dendritic arbor. Nat Neurosci 8, 848–850 (2005). https://doi.org/10.1038/nn0705-848

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