Geometric and functional organization of cortical circuits

Supplementary Fig. 1 (gif 12K)
Geometric input calculation and optimal barrel cortex template. (a) Schematic depicting method used to calculated geometric input from a particular location. See Supplementary Methods for description. (b) Optimal template of the barrel cortex and the respective positions of all recorded and reconstructed neurons. In L2/3, positions of pyramidal cells for which LSPS maps where obtained are marked by green dots (32 cells). Positions of reconstructed cells used to produce potential connectivity maps are marked with red dots in L2/3 (13 pyramidal cells), and blue dots in L4 and L5A (49 spiny stellate and pyramidal cells). Bottom and left axes provide the scale in micrometers. Right axis indicates distance from pia. Numbers to left of right axis indicate widths of laminae.

Supplementary Fig. 2 (gif 36K)
Comparisons of functional and geometric input. (a) Inputs to L2^barrel neurons: i, horizontal profile of functional input; ii, horizontal profile of geometric input; iii, plot of functional versus geometric horizontal profiles. (b) Inputs to L3^barrel neurons. (c) Inputs to L2^septum neurons. (d) Inputs to L3^septum neurons. (e) Plot of the ratios of functional to geometric input. Projections from L4 are indicated by green lines (see inset); those from L5A indicated by blue lines. Home-column projections are indicated by black lines and bars; those from left and right side columns indicated by red lines and bars. Values were calculated using different home-column widths (from 100 to 400 m) and for the side columns separately or combined, as indicated in the boxed annotated example for the L4 L2^barrel projection.

Supplementary Methods (pdf 188K)

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