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Article
Nature Neuroscience  8, 458 - 467 (2005)
Published online: 6 March 2005; | doi:10.1038/nn1416

LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses

Anthone W Dunah, Emily Hueske, Michael Wyszynski, Casper C Hoogenraad, Jacek Jaworski, Daniel T Pak, Alyson Simonetta, Guosong Liu & Morgan Sheng

Supplementary Fig. 1 (pdf 305K)
Expression of endogenous LAR-RPTP in cultured hippocampal neurons.

Supplementary Fig. 2 (pdf 715K)
LAR interfering constructs reduce dendritic spine density in immature hippocampal neurons.

Supplementary Fig. 3 (pdf 322K)
Overexpression of LAR mutants disrupts surface expression of AMPA receptors and dendritic targeting of beta-catenin and cadherin.

Supplementary Fig. 4 (pdf 403K)
Overexpression of wildtype LAR inhibits the effect of dominant negative LAR mutants on surface AMPA receptors and PSD-95 density.

Supplementary Fig. 5 (pdf 157K)
Efficacy and specificity of LAR-RPTP RNAi constructs.

Supplementary Methods (pdf 20K)


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Nature Neuroscience
ISSN: 1097-6256
EISSN: 1546-1726
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