Abstract
The cerebral cortex is interconnected with two major subcortical structures: the basal ganglia and the cerebellum. How and where cerebellar circuits interact with basal ganglia circuits has been a longstanding question. Using transneuronal transport of rabies virus in macaques, we found that a disynaptic pathway links an output stage of cerebellar processing, the dentate nucleus, with an input stage of basal ganglia processing, the striatum.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Alexander, G.E., DeLong, M.R. & Strick, P.L. Annu. Rev. Neurosci. 9, 357–381 (1986).
Graybiel, A.M. Neurobiol. Learn. Mem. 70, 119–136 (1998).
Masterman, D.L. & Cummings, J.L.J. Psychopharmacology 11, 107–114 (1997).
Middleton, F.A. & Strick, P.L. Brain Res. Brain Res. Rev. 31, 236–250 (2000).
Schmahmann, J.D. The Cerebellum and Cognition (Academic, San Diego, 1997).
Jones, E.G. The Thalamus (Plenum, New York, 1985).
Percheron, G., Francois, C., Talbi, B., Yelnik, J. & Fenelon, G. Brain Res. Brain Res. Rev. 22, 93–181 (1996).
Kelly, R.M. & Strick, P.L. J. Neurosci. Methods 103, 63–71 (2000).
Middleton, F.A. & Strick, P.L. J. Neurosci. 21, 700–712 (2001).
Dum, R.P., Li, C. & Strick, P.L. Ann. NY Acad. Sci. 978, 289–301 (2002).
Clower, D.M., Dum, R.P. & Strick, P.L. Cereb. Cortex 15, 913–920 (2005).
Smith, Y., Raju, D.V., Pare, J.F. & Sidibe, M. Trends Neurosci. 27, 520–527 (2004).
Ichinohe, N., Mori, F. & Shoumura, K. Brain Res. 880, 191–197 (2000).
Wichmann, T. & DeLong, M.R. Curr. Opin. Neurobiol. 6, 751–758 (1996).
Doya, K. Curr. Opin. Neurobiol. 10, 732–739 (2000).
Acknowledgements
This work was supported by the Veterans Affairs Medical Research Service; the National Parkinson Foundation; US Department of Health and Human Services grants MH56661, NS047126, RR018604 (P.L.S.) and a long-term fellowship from the Human Frontier Science Program Organization (E.H.). We thank B. Dietzschold and M. Schnell (Thomas Jefferson University, Philadelphia) for supplying rabies virus and A. Wandeler (Animal Disease Research Institute, Nepean, Ontario, Canada) for supplying antibodies to rabies. We thank M. Page for developing the computer programs; C. Lovell, K. McDonald, M. O'Malley, M. Ratajeski and M. Watach for their technical assistance; and D. Akkal, F. Delis, R.P. Dum, D. Hoffman, and J.-A. Rathelot for scientific discussions.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Supplementary information
Supplementary Fig. 1
Experimental paradigm. (PDF 240 kb)
Supplementary Fig. 2
Injection site in putamen, and thalamic neurons labeled by retrograde transneuronal transport of virus from Gpe. (PDF 325 kb)
Supplementary Fig. 3
The cerebellar pathway to the basal ganglia. (PDF 134 kb)
Rights and permissions
About this article
Cite this article
Hoshi, E., Tremblay, L., Féger, J. et al. The cerebellum communicates with the basal ganglia. Nat Neurosci 8, 1491–1493 (2005). https://doi.org/10.1038/nn1544
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn1544
This article is cited by
-
The cerebellum directly modulates the substantia nigra dopaminergic activity
Nature Neuroscience (2024)
-
Dopamine receptors of the rodent fastigial nucleus support skilled reaching for goal-directed action
Brain Structure and Function (2023)
-
Does Vestibular Motion Perception Correlate with Axonal Pathways Stimulated by Subthalamic Deep Brain Stimulation in Parkinson’s Disease?
The Cerebellum (2023)
-
Basal ganglia-cortical connectivity underlies self-regulation of brain oscillations in humans
Communications Biology (2022)
-
Intracranial direct electrical mapping reveals the functional architecture of the human basal ganglia
Communications Biology (2022)