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Neurobehavioral assessment in the information age

Nature Neuroscience volume 7, pages 462–466 (2004)Cite this article

Abstract

The elucidation of the human and mouse genomes provides new opportunities for exploring the genetic underpinnings of complex mammalian behaviors. This information also provides new windows into the pathophysiology and treatment of neuropsychiatric diseases. Optimal use of the rapidly escalating numbers of mouse lines engineered for these purposes is hindered, however, by practical and theoretical limitations of common behavioral analyses. New strategies combining automated behavioral monitoring and information technologies are currently under development in both academic and industrial settings. These hold promise, both for improving the throughput of mouse behavioral assessment and for providing new insights into the neurobiology of mammalian behavioral regulation.

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Author information

Authors and Affiliations

  1. Center for Neurobiology & Psychiatry and Institute for Neurodegenerative Diseases, University of California San Francisco School of Medicine, 401 Parnassus Avenue, San Francisco, 94143-0984, California, USA

    Laurence H Tecott

  2. Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, 75390-9070, Texas, USA

    Eric J Nestler

Authors
  1. Laurence H Tecott
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  2. Eric J Nestler
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Correspondence to Laurence H Tecott.

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Competing interests

E.J.N. reports financial interests in PsychoGenics, Inc., a biotech company invested in development of high-throughput behavioral assays.

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Tecott, L., Nestler, E. Neurobehavioral assessment in the information age. Nat Neurosci 7, 462–466 (2004). https://doi.org/10.1038/nn1225

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