Distant influences of amygdala lesion on visual cortical activation during emotional face processing

Supplementary Fig. 1 (pdf 232K)
Main effect of facial expression (fearful minus neutral faces, irrespective of spatial attention). (Upper row) Right amygdala activation overlaid on the mean anatomical scan for each group separately: N = normal controls; H = patients with hippocampal damage only; AH = patients with both amygdala and hippocampus damage. (Lower row) Parameter estimates of activity in right amygdala across all stimulus conditions, for each group, showing increased responses to fearful faces both when these appeared at task-relevant locations and when they appeared at task-irrelevant locations. This pattern corroborates our previous findings in a different group of healthy participants in the same paradigm¹¹. See table 2 for coordinates and statistical data..

Supplementary Fig. 2 (pdf 149K)
Correlations between T2 sclerosis intensity in amygdala and magnitude of emotional activation (fearful minus neutral faces). Such correlations are shown for different regions in the ipsilateral or contralateral hemisphere, across the 26 patients (from AH and H groups). As for the left amygdala and left fusiform shown in Figure 4D of main paper, there was a reliable inverse relationship between (a) left amygdala and left occipital cortex when faces were either task-relevant or task-irrelevant (R = −0.48 and −0.36, respectively) but not between (b) right amygdala and left fusiform (R = 0.12 and 0.11). Similarly, there was no correlation between (c) right fusiform increases and left amygdala sclerosis (R = −0.18 and 0.02), but (d) a reliable negative correlation between right fusiform and right amygdala (R = −0.39 and −0.48). These data illustrate the consistently ipsilateral nature of functional relationships between structural amygdala integrity and functional modulation of visual responses to emotional faces, irrespective of task-relevance.

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