Syncytin is a viral envelope protein encoded in the human genome. New work in this issue indicates that it is activated in multiple sclerosis astrocytes and microglia, contributing to the inflammation-induced myelin destruction that causes disease symptoms.
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Mattson, M., Taub, D. Ancient viral protein enrages astrocytes in multiple sclerosis. Nat Neurosci 7, 1021–1023 (2004). https://doi.org/10.1038/nn1004-1021
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DOI: https://doi.org/10.1038/nn1004-1021
