Journal home
Advance online publication
Current issue
Archive
Press releases
Supplements
Focuses
Guide to authors
Online submissionOnline submission
Permissions
For referees
Free online issue
Contact the journal
Subscribe
Advertising
work@npg
naturereprints
About this site
For librarians
 
NPG Resources
Nature
Nature Reviews Neuroscience
Nature Cell Biology
Nature Medicine
Neuroscience Gateway
UCSD-Nature Signaling Gateway
NPG Subject areas
Biotechnology
Cancer
Chemistry
Clinical Medicine
Dentistry
Development
Drug Discovery
Earth Sciences
Evolution & Ecology
Genetics
Immunology
Materials Science
Medical Research
Microbiology
Molecular Cell Biology
Neuroscience
Pharmacology
Physics
Browse all publications
Brief Communication
Nature Neuroscience  5, 627 - 628 (2002)
Published online: 3 June 2002; | doi:10.1038/nn863

Dyskinesias following neural transplantation in Parkinson's disease

Peter Hagell1, 4, Paola Piccini6, Anders Björklund2, Patrik Brundin3, Stig Rehncrona5, Håkan Widner3, 4, Lesley Crabb7, Nicola Pavese6, Wolfgang H. Oertel9, Niall Quinn8, David J. Brooks6 & Olle Lindvall1, 4

1  Section of Restorative Neurology, Wallenberg Neuroscience Center, SE-221 84 Lund, Sweden

2  Division of Neurobiology, Wallenberg Neuroscience Center, SE-221 84 Lund, Sweden

3  Section for Neuronal Survival, Wallenberg Neuroscience Center, SE-221 84 Lund, Sweden

4  Division of Neurology, Department of Clinical Neuroscience, University Hospital, SE-221 85 Lund, Sweden

5  Division of Neurosurgery, Department of Clinical Neuroscience, University Hospital, SE-221 85 Lund, Sweden

6  MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK

7  National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK

8  Sobell Department of Motor Neuroscience and Movement Disorders, Queen Square, London, WC1N 3BG, UK

9  Department of Neurology, University of Marburg, DE-35033 Marburg, Germany

Correspondence should be addressed to Olle Lindvall olle.lindvall@neurol.lu.se
Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue1. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by 18F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopaminergic neurons.


MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated

RESEARCH
Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient
Nature Neuroscience Article (01 Dec 1999)

 Top
Abstract
Previous | Next
Table of contents
Full textFull text
Download PDFDownload PDF
Send to a friendSend to a friend
Save this linkSave this link

Open Innovation Challenges

naturejobs

Figures & Tables
Supplementary info
Export citation
natureproducts

Search buyers guide:

 
ADVERTISEMENT
 
Nature Neuroscience
ISSN: 1097-6256
EISSN: 1546-1726
Journal home | Advance online publication | Current issue | Archive | Press releases | Supplements | Focuses | For authors | Online submission | Permissions | For referees | Free online issue | About the journal | Contact the journal | Subscribe | Advertising | work@npg | naturereprints | About this site | For librarians
Nature Publishing Group, publisher of Nature, and other science journals and reference works©2002 Nature Publishing Group | Privacy policy