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Scientific Correspondence
Nature Neuroscience 2, 861–863 (1 October 1999) | doi:10.1038/13158
Brain development during childhood and adolescence: a longitudinal MRI study
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Abstract
Pediatric neuroimaging studies, up to now exclusively cross sectional, identify linear decreases in cortical gray matter and increases in white matter across ages 4 to 20. In this large-scale longitudinal pediatric neuroimaging study, we confirmed linear increases in white matter, but demonstrated nonlinear changes in cortical gray matter, with a preadolescent increase followed by a postadolescent decrease.
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