News and Views


Nature Neuroscience 12, 815 - 817 (2009)
doi:10.1038/nn0709-815

Genetics meets epigenetics: HDACs and Wnt signaling in myelin development and regeneration

Huiliang Li1 & William D Richardson1

  1. The authors are at the Wolfson Institute for Biomedical Research and Research Department of Cell and Developmental Biology, University College London, London, UK.

Correspondence to: William D Richardson1 e-mail: w.richardson@ucl.ac.uk


A study shows that the histone deacetylases HDAC1 and HDAC2 stimulate oligodendrocyte differentiation by antagonizing the inhibitory action of Wnt signaling, linking genetic and epigenetic control of oligodendrocyte development.

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