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PML: a tumor suppressor essential for neocortical development

Nature Neuroscience volume 12, pages 108–110 (2009)Cite this article

Brain development requires precise control of progenitor proliferation and differentiation. PML appears to be a crucial regulator of cortical progenitors, limiting proliferation and promoting the generation of committed neuronal precursors.

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Figure 1: PML regulates neocortical progenitors through interactions with pRb.

Kim Caesar

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Authors and Affiliations

  1. Karisa C. Schreck is at the Institute for Cell Engineering and the Department of Neuroscience, and Nicholas Gaiano is at the Institute for Cell Engineering and the Departments of Neurology, Neuroscience and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. kschreck@jhmi.edu or gaiano@jhmi.edu.,

    Karisa C Schreck & Nicholas Gaiano

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  1. Karisa C Schreck
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  2. Nicholas Gaiano
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Schreck, K., Gaiano, N. PML: a tumor suppressor essential for neocortical development. Nat Neurosci 12, 108–110 (2009). https://doi.org/10.1038/nn0209-108

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