Brief Communication abstract
Nature Neuroscience 11, 998 - 1000 (2008)
Published online: 10 August 2008 | doi:10.1038/nn.2167
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
Qingchun Tong1, Chian-Ping Ye1, Juli E Jones1, Joel K Elmquist2 & Bradford B Lowell1
The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron–specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.
- Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave., Boston, Massachusetts 02215, USA
- Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Correspondence to: Bradford B Lowell1 e-mail: blowell@bidmc.harvard.edu
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