Brief Communication abstract
Nature Neuroscience 11, 868 - 870 (2008)
Published online: 11 July 2008 | doi:10.1038/nn.2150
The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation
Laurent Groc1, Daniel Choquet1 & Francis Chaouloff2
Corticosterone facilitates hippocampal glutamate transmission, but the cellular pathways by which AMPA receptor (AMPAR) signaling is adjusted remain elusive. Single quantum-dot imaging in live rat hippocampal neurons revealed that corticosterone triggers, via distinct corticosteroid receptors, time-dependent increases in GluR2-AMPAR surface mobility and synaptic surface GluR2 content. Furthermore, corticosterone potentiates the increase of synaptic surface GluR2 contents by a chemical long-term potentiation stimulus, revealing the influence that corticosterone has on AMPAR trafficking.
- Physiologie Cellulaire de la Synapse, UMR 5091 CNRS, Université Bordeaux 2, Bordeaux 33077, France.
- Centre de Recherches INSERM U862, Equipe AVENIR Mécanismes Moléculaires de l'Adaptation, Université Bordeaux 2, 33077 Bordeaux, France.
Correspondence to: Laurent Groc1 e-mail: laurent.groc@u-bordeaux2.fr
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