Brief Communication abstract
Nature Neuroscience 11, 741 - 743 (2008)
Published online: 30 May 2008 | doi:10.1038/nn.2127
Critical role of TRPC6 channels in the formation of excitatory synapses
Jian Zhou1,2,3, Wanlu Du1,2,3, Kechun Zhou1,2, Yilin Tai1,2, Hailan Yao1,2, Yichang Jia1,2, Yuqiang Ding1 & Yizheng Wang1
The transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels with different biological functions, but their roles in brain are largely unknown. Here we report that TRPC6 was localized to excitatory synapses and promoted their formation via a CaMKIV-CREB–dependent pathway. TRPC6 transgenic mice showed enhancement in spine formation, and spatial learning and memory in Morris water maze. These results reveal a previously unknown role of TRPC6 in synaptic and behavioral plasticity.
- Laboratory of Neural Signal Transduction, Institute of Neuroscience, Shanghai Institutes of Biological Sciences, State Key Laboratory of Neuroscience, Shanghai 200031, China.
- The Graduate School, Chinese Academy of Science, Shanghai 200031, China.
- These authors contributed equally to this work.
Correspondence to: Yizheng Wang1 e-mail: yzwang@ion.ac.cn
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