Neurotrophins are recognized for their role in sustaining neuron survival and promoting axon growth. New studies reveal that they can also facilitate both neuron death and axon pruning by mechanisms that have much in common.
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References
Deppmann, C.D. et al. Science 320, 369–373 (2008).
Singh, K.K., et al. Nat. Neurosci. 11, 649–658 (2008).
Bamji, S.X. et al. J. Cell Biol. 140, 911–923 (1998).
Singh, K.K. & Miller, F.D. Neuron 45, 837–845 (2005).
Cao, L. et al. Curr. Biol. 17, 911–921 (2007).
Glebova, N.O. & Ginty, D.D. Annu. Rev. Neurosci. 28, 191–222 (2005).
Davies, A.M. et al. Nature 326, 353–358 (1987).
Korsching, S. & Thoenen, H. Dev. Biol. 126, 40–46 (1988).
Wyatt, S. & Davies, A.M. J. Cell Biol. 130, 1435–1446 (1995).
Horton, A. et al. Mol. Cell. Neurosci. 10, 162–172 (1997).
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Davies, A. Neurotrophins giveth and they taketh away. Nat Neurosci 11, 627–628 (2008). https://doi.org/10.1038/nn0608-627
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DOI: https://doi.org/10.1038/nn0608-627