Brief Communication abstract
Nature Neuroscience 11, 631 - 633 (2008)
Published online: 23 April 2008 | doi:10.1038/nn.2120
Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri
Feng Zhang1, Matthias Prigge2, Florent Beyrière2, Satoshi P Tsunoda2, Joanna Mattis1, Ofer Yizhar1, Peter Hegemann2 & Karl Deisseroth1
The introduction of two microbial opsin–based tools, channelrhodopsin-2 (ChR2) and halorhodopsin (NpHR), to neuroscience has generated interest in fast, multimodal, cell type–specific neural circuit control. Here we describe a cation-conducting channelrhodopsin (VChR1) from Volvox carteri that can drive spiking at 589 nm, with excitation maximum red-shifted 
70 nm compared with ChR2. These results demonstrate fast photostimulation with yellow light, thereby defining a functionally distinct third category of microbial rhodopsin proteins.
- Departments of Bioengineering and Psychiatry, W083 Clark Center, 318 Campus Drive, Stanford University, Stanford, California 94305, USA.
-
Institute of Biology, Experimental Biophysics, Humboldt-University, Invalidenstra
e 42, D-10115 Berlin, Germany.
Correspondence to: Peter Hegemann2 e-mail: hegemape@rz.hu-berlin.de
Correspondence to: Karl Deisseroth1 e-mail: deissero@stanford.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Body mass index is associated with altered renal hemodynamics in non-obese healthy subjectsKidney International Original Article
Site-specific DNA binding using a variation of the double stranded RNA binding motifNature Structural Biology Letter (01 Jul 1998)
Multimodal fast optical interrogation of neural circuitryNature Article (05 Apr 2007)
See all 14 matches for Research
