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Nature Neuroscience 11, 209–215 (1 February 2008) | doi:10.1038/nn2037

Reactivation of experience-dependent cell assembly patterns in the hippocampus

Joseph O'Neill , Timothy J Senior , Kevin Allen , John R Huxter & Jozsef Csicsvari

The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places increased relative to the sleep session before exploration. This cofiring increase depended on the number of times that cells fired together with short latencies (