Article abstract
Nature Neuroscience 11, 1392 - 1401 (2008)
Published online: 8 October 2008 | doi:10.1038/nn.2220
PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Leanne E Rivers1,3, Kaylene M Young1,3, Matteo Rizzi1,3, Françoise Jamen1,2,3, Konstantina Psachoulia1, Anna Wade1,2, Nicoletta Kessaris1 & William D Richardson1
Abstract
Platelet-derived growth factor 
receptor (PDGFRA)/NG2–expressing glia are distributed throughout the adult CNS. They are descended from oligodendrocyte precursors (OLPs) in the perinatal CNS, but it is not clear whether they continue to generate myelinating oligodendrocytes or other differentiated cells during normal adult life. We followed the fates of adult OLPs in Pdgfra-creERT2/Rosa26-YFP double-transgenic mice and found that they generated many myelinating oligodendrocytes during adulthood; >20% of all oligodendrocytes in the adult mouse corpus callosum were generated after 7 weeks of age, raising questions about the function of the late-myelinating axons. OLPs also produced some myelinating cells in the cortex, but the majority of adult-born cortical cells did not appear to myelinate. We found no evidence for astrocyte production in gray or white matter. However, small numbers of projection neurons were generated in the forebrain, especially in the piriform cortex, which is the main target of the olfactory bulb.
- Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.
- Present addresses: CNRS Institut de Neurobiologie Alfred Fessard, 91198 Gif-sur-Yvette, France (F.J.); University College London Institute of Neurology, Queen's Square, London WC1N 3BG, UK (A.W.).
- These authors contributed equally to this work.
Correspondence to: William D Richardson1 e-mail: w.richardson@ucl.ac.uk
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