Brief Communication abstract
Nature Neuroscience 11, 16 - 18 (2008)
Published online: 25 November 2007 | doi:10.1038/nn2016
Recognition memory: opposite effects of hippocampal damage on recollection and familiarity
Magdalena M Sauvage1, Norbert J Fortin1, Cullen B Owens1, Andrew P Yonelinas1 & Howard Eichenbaum1
A major controversy in memory research concerns whether recognition is subdivided into distinct cognitive mechanisms of recollection and familiarity that are supported by different neural substrates. Here we developed a new associative recognition protocol for rats that enabled us to show that recollection is reduced, whereas familiarity is increased following hippocampal damage. These results provide strong evidence that these processes are qualitatively different and that the hippocampus supports recollection and not familiarity.
- Center for Memory and Brain, Boston University, 2 Cummington Street, Boston, Massachusetts 02215, USA.
Correspondence to: Howard Eichenbaum1 e-mail: hbe@bu.edu
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