1. The author is at the Research Centre of the Centre Hospitalier Université Laval, Laval University, 2705 boul. Laurier, Sainte-Foy, Québec G1V4G2, Canada. e-mail: jean-pierre.julien@crchul.ulaval.ca

Abstract

Amyotrophic lateral sclerosis (ALS) is characterized by the selective degeneration of motor neurons. Two independent studies in this issue show that astrocytes expressing a mutation in the enzyme superoxide dismutase can exacerbate motor neuron death, supporting previous suggestions that non-neuronal cells contribute to ALS pathogenesis.

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