Article abstract
Nature Neuroscience 10, 444 - 452 (2007)
Published online: 18 March 2007 | doi:10.1038/nn1875
Dendritic development and plasticity of adult-born neurons in the mouse olfactory bulb
Adi Mizrahi1
Abstract
The mammalian brain maintains few developmental niches where neurogenesis persists into adulthood. One niche is located in the olfactory system where the olfactory bulb continuously receives functional interneurons. In vivo two-photon microscopy of lentivirus-labeled newborn neurons was used to directly image their development and maintenance in the olfactory bulb. Time-lapse imaging of newborn neurons over several days showed that dendritic formation is highly dynamic with distinct differences between spiny neurons and non-spiny neurons. Once incorporated into the network, adult-born neurons maintain significant levels of structural dynamics. This structural plasticity is local, cumulative and sustained in neurons several months after their integration. Thus, I provide a new experimental system for directly studying the pool of regenerating neurons in the intact mammalian brain and suggest that regenerating neurons form a cellular substrate for continuous wiring plasticity in the olfactory bulb.
- Department of Neurobiology, Institue for Life Sciences and the Interdisciplinary Center for Neural Computation, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, 91904, Israel.
Correspondence to: Adi Mizrahi1 e-mail: mizrahia@cc.huji.ac.il
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