News and Views

Nature Neuroscience 10, 271 - 273 (2007)
doi:10.1038/nn0307-271

Astrocytes target presynaptic NMDA receptors to give synapses a boost

Rheinallt Parri1 & Vincenzo Crunelli2

  1. Rheinallt Parri is at the School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK.
  2. Vincenzo Crunelli is at the School of Biosciences, Cardiff University, Cardiff CF10 3US, UK. e-mail: crunelli@cardiff.ac.uk

Astrocytes modulate synaptic strength. This effect occurs, reports a new paper, because ATP-dependent vesicular release of astrocytic glutamate acts on presynaptic neuronal NMDA receptors to increase synaptic efficacy.

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