Brief Communication abstract
Nature Neuroscience 10, 1515 - 1517 (2007)
Published online: 4 November 2007 | doi:10.1038/nn2001
GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI
Georg Northoff1, Martin Walter1, Rolf F Schulte2, Johannes Beck3, Ulrike Dydak2, Anke Henning2, Heinz Boeker3, Simone Grimm3 & Peter Boesiger2
Abstract
The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level–dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in the ACC specifically correlated with the amount of negative BOLD responses in the very same region. Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA.
- Department of Psychiatry, Otto-von-Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany.
- Institute for Biomedical Engineering, University and ETH Zuerich, Gloriastrasse 35, 8092 Zürich, Switzerland.
- Department of Psychiatry, University of Zuerich, Lenggstrsse 31, 8029 Zürich, Switzerland.
Correspondence to: Georg Northoff1 e-mail: georg.northoff@medizin.uni-magdeburg.de
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